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Jmol (loading on the left) Viewing Instructions Rotate: Click and drag Zoom in/out: Hold shift while clicking and dragging Right Click for more options The molecule on the left is HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (Complex P).  Our LabWe work towards unraveling the molecular details of how biomedically-relevant enzymes function, how they are inhibited, how they develop drug resistance and towards developing drugs that will treat human disease. In pursuit of these goals we use a combination of conventional and cutting-edge research tools, including protein biochemistry, molecular biology, macromolecular engineering, molecular modeling, X-ray crystallography, surface plasmon resonance (Biacore), enzymology, and high-throughput technologies. Target proteins include HIV-1 reverse transcriptase, SARS RNA-dependent RNA polymerase (RdRp), Foot-and-Mouth Disease Virus (FMDV) replicase, Dengue Virus replicase, Hepatitis C Virus (HCV) RdRp, Hepatitis B Virus (HBV) reverse transcriptase, Bovine Immunodefficiency Virus (BIV) Reverse Transcriptase, and bacterial RNA polymerases. |